Hair loss is a common worry for many people, and the search for effective solutions can be overwhelming. Whether it's trying traditional remedies or exploring the latest treatments, the options seem endless.In this quest, one promising solution that has gained attention is RU58841.
It offers a different approach to addressing hair loss, and in this blog, we'll talk about it in detail including where to buy it, how to use it, and its effectiveness with scientific studies.
What is RU58841?
RU58841 isn't a recent creation. French scientists initially developed it in the 1970s while looking for a treatment for prostate cancer. They created RU58841 as a non-steroidal, antiandrogenic substance for topical application to minimize overall side effects.
After testing it on rats, they observed that it encouraged hair growth. The researchers believed that RU58841 could be beneficial for treating androgen-dependent skin conditions like acne and alopecia when applied topically.
However, before they could proceed with additional research or production plans, their company merged with two others. Eventually, for reasons that remain unclear, the project was abandoned.
A few years later, a company named ProStrakan obtained the rights to RU58841. ProStrakan changed the drug's name to PSK3841.
In 2005, the company announced intentions to conduct a Phase II trial with a full launch planned for 2010. While Phase I and II trials took place, Phase III research never commenced.
Presently, there is no ongoing research on RU58841. Unless there's a significant development, this drug will likely never reach the market. As of today, it's not only unlicensed for treating hair loss but also not approved for human use.
- Non-Steroidal: Unlike some treatments that involve hormones, RU58841 is non-steroidal. So it is a distinct choice for those looking to avoid hormonal interventions.
- Topical Application: One of its notable features is its application method. RU58841 is usually applied topically, directly to the scalp for a targeted and localized approach.
Mechanisms of Action
RU58841 operates by attaching itself to the androgen receptors in the scalp. Androgens, such as dihydrotestosterone (DHT), are associated with hair loss. By binding to these receptors, RU58841 aims to disrupt the negative impact of androgens on hair follicles. Essentially, it strives to create a shield against the factors that contribute to hair thinning and loss.
In simple terms, RU58841 acts as a protective barrier for hair follicles to prevent the damaging effects of androgens, thus promoting hair retention and potential regrowth.
Where to Buy RU58841?
For those considering RU58841 as a potential solution to hair loss, finding a reliable source is very very important. Here, we'll provide an overview of reputable sources and offer guidance on making a safe and informed purchase.
Reputable Sources and Suppliers
Some online platforms specialize in hair loss treatments and have established credibility. Look for reputable websites that have a track record of providing genuine products.
Some individuals also go for compounding pharmacies that create custom formulations. Make sure these pharmacies follow regulatory standards and have a reputation for quality.
Online forums and communities can be valuable resources. Seek recommendations from users who have had positive experiences with specific suppliers.
Before making a purchase, check customer reviews and testimonials. Positive feedback from previous buyers can indicate the reliability of a supplier. A trustworthy supplier will provide clear information about the product, including its origin, formulation, and usage instructions.
Tips on Avoiding Scams or Counterfeit Products
- Beware of Unrealistic Claims: If a supplier makes extravagant claims about the effectiveness of their RU58841 or promises immediate results, exercise caution. Authentic products are more likely to provide realistic expectations.
- Secure Payment Options: Use secure payment methods to protect your financial information. Avoid suppliers who only accept unconventional or untraceable payment methods.
- Research the Supplier: Conduct thorough research on the supplier's reputation. Check for any history of legal issues, and verify their credentials.
A common concern is the prevalence of under-dosed products in the market. Some sellers promise a strong 5% concentration of products like RU58841 but end up delivering a weaker 2%. This not only makes the product less effective but also makes it hard for people to trust these solutions.
MV Supplement is a reliable and transparent option. We are committed to delivering what we promise. Unlike many others, we guarantee the purity of our RU58841 and ensure that the concentration matches what's written on the label.
To be even more transparent, we encourage our customers to independently test our products in a lab. We believe that customers should be sure they are using high-quality products. If the lab test results show any difference from what we promised, we're ready to cover the cost of the lab test. This not only builds trust in our product but also shows our dedication to keeping our customers satisfied.
Our reputation is based on consistently providing high-quality RU58841 to people all over Europe.
Effectiveness of RU58841
The safety and effectiveness of RU58841 are quite remarkable, as evident in before-and-after comparisons like the one below.
RU58841's unique feature, not interfering with DHT and testosterone synthesis, makes it a promising drug. Importantly, concerns about side effects like erectile dysfunction, often associated with finasteride, are minimized.
How to Use RU58841
RU58841 is available in pre-made solution or raw powder form. The pre-made solution has a 5% concentration of RU58841 at 50 mg/ml. The raw powder suits those wanting more control over concentration or wishing to mix it with minoxidil.
Note that RU58841 lacks FDA approval, so cautious use is essential, considering both safety and economic factors.
Start Low, Go Slow: It's generally advisable to begin with a lower dosage and gradually increase it. This helps assess how your body responds to RU58841.
Typical Dosage Range: The typical dosage for RU58841 ranges from 50mg to 100mg per day. However, individual responses may vary, and it's essential to find the dosage that works best for you.
Consult with a Professional: Before starting any new treatment, especially for a long-term concern like hair loss, it's wise to consult with a healthcare professional. They can provide personalized advice based on your health history.
RU58841 is commonly applied topically, directly to the scalp. This localized application targets the affected areas, providing a focused approach to combat hair loss.
If you're using a solution, follow the preparation instructions provided by the supplier. This often involves diluting the RU58841 with a carrier solution for ease of application.
Also make sure your scalp is clean and dry before application. This allows for better absorption of the solution. To ensure accurate and even application, consider using an applicator or dropper provided by the supplier.
Frequency and Duration Recommendations
The frequency of RU58841 application can vary. Some users apply it daily, while others opt for less frequent use, such as every other day. The key is consistency.
RU58841 is often used as a long-term solution. Hair growth and maintenance take time, so it's important to be patient and stick to the regimen.
Simple Application Procedure:
- Using a dropper, apply 1 ml of the 5% solution to areas with hair loss.
- Gently rub and spread it with your fingertips to ensure even coverage.
- Let it dry for about a minute.
The subsequent steps depend on concurrent use of other hair treatments. For example, if using minoxidil, this is the ideal time for its application.
When to Apply RU58841
While there's no fixed timeframe, applying RU58841 once daily for at least six months is recommended for noticeable improvement.
Consider that your skin produces sebum (oil), which reduces RU58841's penetrative effectiveness. Applying it 20-30 minutes after a shower can enhance penetration and overall effectiveness.
Additional Application Technique
RU58841 is a watery formulation. Apply it carefully on the scalp, behind the hairline, and spread it over the target area. Take care to prevent it from trickling onto the forehead, sides of the face, or neck, as this may lead to increased hair thickness in those regions over time.
Controlled Study of the Effects of RU58841 on Human Hair Production
In this study conducted by Brouwer et al, 20 productive scalp grafts were taken from middle-aged, bald men. These grafts were then transplanted onto nude mice and observed for a period of 8 months. Notably, the grafted scalp skin, when treated appropriately, could survive after transplantation onto mice, offering a convenient method to potentially study effects on humans.
All mice in the study were subjected to topical application of testosterone on the non-grafted flank. This conditioning with testosterone was done because previous research indicated that it inhibits the growth of transplanted human grafts. The researchers aimed to investigate whether RU58841 could overcome this testosterone-induced inhibition.
The twenty mice were randomly assigned to either the RU58841 experimental group or the control group. In the experimental group, the grafted mice were topically applied with a 1 percent RU58841 solution, while the control group received a topical application of an ethanol solution.
These solutions were applied five days a week over a span of six months, and the results were recorded.
On the control grafts, a total of 28 active follicles appeared, with only two follicles (7%) initiating a second hair cycle. On the RU-58841 grafts, a total of 29 active follicles appeared, and eight of them showed a second growth cycle.
While RU58841 did not lead to more new active follicles, the noteworthy finding was that those follicles that did appear were more likely to function normally over several hair growth cycles.
The researchers concluded that RU58841 may be a valuable treatment for androgen-dependent alopecia in humans based on the observed effects in this controlled study. (Source)
Studies on Humans
Prostrakan, the company that eventually obtained the rights to the drug, conducted two clinical trials involving humans in the early 2000s.
The initial trial was a phase I study in France focused on safety assessment. Thirty men with male pattern baldness applied a 5% solution to their heads twice a day for 4 weeks. Although the results of this study were not officially published, indications suggest they were positive, as the company proceeded to a phase II trial.
The phase II trial compared a placebo to two solutions of RU58841: one with a 2.5% strength and another with a 5% strength. The total sample size comprised 120 balding men who underwent treatment for over 6 months.
Once again, this study's results were not published, leaving us without comprehensive data. However, leaked information suggests that the outcomes were comparable to, if not better than, finasteride.
Following these successful trials, the company intended to move forward with a phase III trial. However, for reasons that remain unclear, this phase III trial never materialized. Some speculate that the drug's instability and limited shelf life might be contributing factors, while others propose that Prostrakan simply deemed the compound not lucrative enough for further development.
Frequently Asked Questions (FAQs)
Here, we address some of the common queries that readers may have about this innovative solution for hair loss.
Q1: What is RU58841, and how does it work?
RU58841 is a non-steroidal anti-androgen developed to combat hair loss, particularly androgenetic alopecia. It works by binding to androgen receptors in the scalp to disrupt the negative impact of androgens on hair follicles and promote hair retention.
Q2: How do I know if RU58841 is right for me?
Consider consulting with a healthcare professional before starting any new hair loss treatment. They can assess your individual health history and guide you on the suitability of RU58841 for your specific needs.
Q3: Where can I buy RU58841, and how can I ensure its quality?
Purchase RU58841 from reputable sources. Look for suppliers with positive customer reviews, transparent product information, and a commitment to purity. Independent lab testing can also provide assurance of the product's quality.
Q4: What is the recommended dosage of RU58841?
The typical dosage is 1ml of 5% solution on the affected area. However, it's advisable to start with a lower dosage and gradually increase while monitoring your body's response. Consulting with a healthcare professional is recommended.
Q5: Can I use RU58841 with other hair loss treatments?
Some individuals combine RU58841 with other treatments like minoxidil or finasteride. However, it's important to consult with a healthcare professional before combining different hair loss solutions to avoid potential interactions.
Q6: How soon can I expect to see results with RU58841?
Hair growth and maintenance take time. Results may vary, but users typically start noticing changes after consistent use over several months. Patience is key in the journey to combat hair loss.
Q7: Are there any side effects of using RU58841?
While side effects are generally minimal, individuals may experience irritation or dryness at the application site. If any adverse reactions occur, discontinue use and consult with a healthcare professional.
Q8: Can women use RU58841?
While research on RU58841 is primarily focused on men, some women choose to use it. As with any treatment, consulting with a healthcare professional is advised, especially for women who are pregnant or breastfeeding.
Q9: Is RU58841 a permanent solution for hair loss?
RU58841 is often used as a long-term solution. Hair loss management requires ongoing care, and consistent use of RU58841 is recommended for maintaining results.
At MV Supplements, we've been a reliable source for RU58841 and Pyrilutamide. Our commitment is simple, transparency and purity. We guarantee the quality of our RU58841, and we even encourage customers to independently test our products. If it doesn't meet our promises, we'll cover the lab test cost – that's how dedicated we are to your satisfaction.
So, if you're ready to take on hair loss with RU58841, visit our store, explore our products, and trust us to be your partner in the journey to regaining your hair.