How Effective is RU58841 for Hair Loss?

Hair loss is a common issue that affects many people and goes beyond just appearance—it impacts us psychologically. It is a widespread condition that impacts nearly 160 million people worldwide (source). Presently, around 700,000 people in the U.S. are dealing with some form of alopecia areata (sudden patchy hair loss) that affects a significant number of people globally.

One substance that has caught everyone’s attention in recent years is RU58841. RU58841 is a chemical compound with the potential to prevent hair loss. It is often considered as a topical solution and is being researched for its effects on androgenetic alopecia, a common type of hair loss. 

In this blog, we will talk about RU58841 and see if it's a promising solution for hair loss. We'll break down how it works, look at scientific studies, hear from people who've used it, and more. 

Common Causes of Hair Loss

Androgenetic Alopecia or hair loss, is one of the most common reasons why people lose their hair. It includes conditions like alopecia areata and androgenetic alopecia. This common form of hair loss impacts around 50 million men and 30 million women in the United States. It can start from one’s teenage and as they get older it becomes more prevalent. More than half of men over 50 experience some level of hair loss due to androgenetic alopecia. (Source)

Hair loss can be attributed to various factors, with genetics and hormonal changes standing out as primary causes. Below we write the most common causes of hair loss.

Genetics

The most common cause of hair loss worldwide is genetic factors. If your family has a history of baldness or thinning hair, there's a higher likelihood that you may experience similar patterns. Around 25% of people assigned male at birth notice their hair thinning before they're 21. By the time they're 50, half of them experience hair loss, and about 70% face it as they get older. Hormones, especially ones called dihydrotestosterone (DHT), are part of the reason for this hair loss.

Hormonal Changes

Hormonal fluctuations during different life stages, such as puberty, pregnancy, and menopause, can disrupt the natural hair growth cycle. Imbalances in hormones, particularly androgens, may lead to the miniaturization of hair follicles, resulting in gradual hair thinning or loss.

Water and Environment

Environmental factors, including water quality, pollution, and exposure to harsh weather conditions, can affect the health of the scalp and hair. Poor water quality and environmental stressors contribute to weakened hair structure and increased vulnerability to damage and loss.

Medical Conditions

Underlying medical conditions, such as thyroid disorders or autoimmune diseases, can disrupt the normal functioning of hair follicles. Chronic illnesses or systemic conditions may lead to hair loss as the body redirects resources away from non-essential functions like hair growth.

Medications

Certain medications, such as those prescribed for cancer, arthritis, depression, heart problems, and high blood pressure, can have hair loss as a side effect. The influence on hair growth is often an unintended consequence of the medication's primary function, affecting the hair cycle and leading to hair thinning or shedding.

Pregnancy

Hormonal changes during pregnancy can lead to temporary hair loss. While some women experience thicker hair during pregnancy, postpartum hormonal shifts can trigger hair shedding. This condition, known as telogen effluvium, is generally temporary, and hair growth tends to normalize after childbirth.

Smoking

Smoking is linked to hair loss as it reduces blood flow to the scalp, affecting hair follicles. The chemicals in tobacco can damage hair and impede its growth. Quitting smoking may improve blood circulation and promote healthier hair.

Diet

Nutritional deficiencies, often stemming from a poor diet, can impact hair health. A lack of essential vitamins and minerals, such as iron, zinc, and vitamin D, may lead to hair thinning or loss. A balanced diet with adequate nutrients is crucial for maintaining healthy hair.

Lifestyle

Stressful lifestyles, insufficient sleep, and a lack of physical activity can contribute to hair loss. Chronic stress may disrupt the hair growth cycle, leading to increased shedding. Adopting stress-management techniques, prioritizing sleep, and staying active can positively influence hair health.

Chemical Products

Overuse of chemical-laden hair products, including dyes and styling agents, can damage hair and lead to loss. Harsh chemicals weaken the hair shaft and may cause breakage. Using products in moderation and opting for gentler alternatives can help preserve the integrity of the hair.

What is RU58841 Chemical? 

RU-58841 also known as PSK-3841 or HMR-3841 is a nonsteroidal antiandrogen (NSAA) chemical that was initially created in the early 1970s by Roussel Uclaf, a French pharmaceutical company as a potential treatment for prostate cancer. The original idea was to apply it topically to have localized effects in the prostate area. 

However, during human trials, it was found ineffective for treating cancer. Interestingly, male subjects in the trials reported increased hair growth in areas where the cream was applied. This led to the chemical being acquired by a company called ProStraken, which renamed it PSK3841. There were plans for further trials and a global launch of RU58841, but no further progress has been made, and its status as a hair loss treatment remains unclear.

Non-steroidal Anti-androgen

RU58841 is classified as a non-steroidal anti-androgen. This means unlike traditional anti-androgenic medications, it doesn't belong to the steroid family. Non-steroidal anti-androgens work by blocking the effects of androgens (male hormones) on the hair follicles without interfering with the body's steroid hormone production. RU58841's specific mechanism as a non-steroidal anti-androgen makes it awesome for hair loss treatments.

How Does RU58841 Work?

RU58841 is a treatment for hair loss that you can only find on the grey market. It's remade from the original formula, exactly as it was tested. 

As time goes on, testosterone turns into DHT. We need a bit of DHT, but having too much starts causing baldness symptoms. This excess DHT sticks to androgen receptors in hair follicles and sets off a series of events that change how genes work. Scientists aren't exactly sure why this happens, but it messes with the hair growth cycle.

The part of the hair growth cycle where hair is lost (anagen phase) starts to take longer. That means hair has less time to grow, and it becomes shorter, thinner, and weaker. Eventually, the hair follicle can't grow hair anymore, and it basically dies.

RU58841 is applied on the skin where you're losing hair. Even though we're not exactly sure how it works, it has been shown to fight against the effects of DHT. It stops DHT from sticking to the androgen receptors in hair follicles. Over time, this helps the hair growth cycle and follicles to stabilize and maybe even recover.

This recovery can be so good that the hair growth might become stronger than it ever was before for that person.

Availability and Legality

RU58841 is not as widely accessible as some mainstream hair loss treatments. Interested individuals may find it through online suppliers or speciality stores like MV Supplements. The legal status of RU58841 can also differ across regions. In some places, it may be available for personal use, while in others, it might be subject to regulations. At MV Supplements, we offer easy and fast delivery of this in Europe.

A Controlled Study of the Effects of RU58841, on Human Hair Production

In a controlled study, researchers investigated the impact of RU58841, a non-steroidal antiandrogen, on human hair growth using a unique model. They transplanted scalp samples from men with androgen-dependent alopecia onto female nude mice conditioned with testosterone. 

The study observed 20 scalp grafts for 8 months, treating half with RU58841 and the other half with a control. The RU58841-treated grafts showed a higher percentage of active follicles initiating a second hair cycle compared to the control group, with significantly increased linear hair growth rates. These positive outcomes suggest RU58841's potential in treating androgen-dependent alopecia, warranting further clinical trials. Source

Benefits and Potential Side Effects

Users have reported several potential benefits of using RU58841 for hair loss prevention. These include a reduction in hair thinning, increased hair density, and improved overall hair health. Some individuals suggest that RU58841 may offer an alternative for those who experience side effects or have concerns about traditional treatments like finasteride.

RU58841, as an anti-androgenic treatment, offers realistic results with its topical application focused on the scalp. Here are key facts about 

RU58841 and what to expect

Anti-Androgenic Nature: RU58841 is anti-androgenic, targeting factors contributing to hair loss.

Topical Application: It doesn't require oral consumption, as it is applied topically to the scalp.

Localized Effects: Its topical nature concentrates on the scalp, minimizing body-wide androgenic side effects.

Follicular Regrowth: Encourages a return to normal follicular regrowth, potentially reversing hair loss.

Anagen Cycle Normalization: Encourages the normalization of the anagen cycle length, a phase critical for hair growth.

DHT Binding Inhibition: Stops DHT binding to androgen receptors in the scalp, addressing a key factor in hair loss.

No Blockage of Hormone Production: It does not block or alter DHT and testosterone production.

Realistic Results

Slowdown in Hair Loss: Visible within six months, it slows hair loss significantly and may delay total hair loss for years with regular use.

Halting Hair Loss: Even without regrowth, RU58841 can entirely stop ongoing hair loss.

Hair Regrowth: In over 70% of cases, there's evidence of hair loss reversal, leading to thicker and longer regrowth, even from dormant follicles.

Combined Treatments

RU58841 and Minoxidil

Combining RU58841 with Minoxidil yields promising results, possibly due to their complementary approaches. While RU58841 alone often produces better results, the combination can enhance overall effectiveness.

Caution with Minoxidil

Using Minoxidil topically may increase side effects. Combining it with RU58841 might offer benefits but be mindful of potential side effects, both general and androgenic.

Conclusion

In summary, RU58841 shows promise in slowing, halting, and even reversing hair loss when used consistently. We recommend that, before considering RU58841, individuals should consult with a healthcare professional to assess potential risks and benefits based on their specific health profile. 

After reading this blog, we hope you decided whether RU58841 is a good solution for your hair loss problem or not. If you need the best quality product, don't forget to have a look at our store MV Supplement. We provide fast delivery all over eu